PRM FAQs: Everything You Need to Know About Pro-Resolving Mediators
The more we learn about the role that chronic inflammation plays in our longevity and performance, the more we look to Pro-Resolving Mediators (PRMs) as an innovative tool in safely offsetting the negative effects of inflammation.
But what exactly are PRMs, and how can they benefit you? In this article we’ll answer the common questions about PRMs, breaking down their science, benefits, and practical applications, with insights from scientific literature.
What Are PRMs?
PRMs, short for Pro-Resolving Mediators, are specialized lipid compounds derived from omega-3 fatty acids such as EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid). Unlike traditional anti-inflammatory approaches that suppress inflammation, PRMs actively work to resolve it by supporting the body’s natural inflammation resolution process (Serhan & Levy, 2018).
When your body experiences inflammation—whether from exercise, injury, or illness it’s not just the onset of inflammation that matters, the resolution phase is equally critical. PRMs help by:
-
Clearing cellular debris and promoting tissue repair (Serhan et al., 2015).
-
Inhibiting excessive inflammation that can lead to chronic conditions (Chiang & Serhan, 2020).
-
Supporting immune homeostasis and recovery from injury (Basil & Levy, 2016).
In simple terms, PRMs ensure your body completes the natural inflammation cycle, preventing prolonged or chronic inflammation.
Why Are PRMs Important for Athletes and High Performers?
Whether you’re an athlete or someone pushing physical limits, inflammation is a natural part of recovery. However, prolonged or unresolved inflammation can hinder performance and increase injury risk. Here’s why PRMs are a game-changer:
-
Faster Recovery
PRMs accelerate the resolution of post-exercise inflammation, reducing muscle soreness and promoting quicker recovery (Dalli & Serhan, 2012).
-
Joint and Tissue Health
By resolving low-grade chronic inflammation, PRMs help protect against long-term joint and tissue damage, which is common in overuse injuries (Serhan et al., 2015).
-
Non-Disruptive to Adaptation
Unlike NSAIDs, which may blunt the muscle adaptation process, PRMs naturally resolve inflammation without interfering with strength and endurance gains (Markworth et al., 2014).
For high performers, PRMs offer a targeted solution to recover effectively and stay competitive without relying on pharmaceuticals.
How Are PRMs Different From Omega-3s?
While omega-3s like EPA and DHA are precursors to PRMs, not all omega-3 supplements contain PRMs themselves. PRMs are the active metabolites your body produces from omega-3s, which directly mediate the resolution of inflammation (Serhan et al., 2015). PRM supplements deliver these bioactive compounds directly, offering a more targeted approach.
Are PRMs Safe?
Yes, PRMs are safe and well-tolerated. Unlike NSAIDs, PRMs don’t carry the risk of gastrointestinal issues or interfere with muscle adaptation. However, individuals on blood-thinning medications or with specific health conditions should consult a healthcare provider before use (Basil & Levy, 2016).
Conclusion
Pro-resolving mediators represent a paradigm shift in inflammation management, offering a natural, efficient, and evidence-based way to optimize recovery and support long-term health.
PRMs are designed to help you recover smarter, perform better, and stay ahead of inflammation.
At Spoken, we’re committed to delivering the highest-quality supplements backed by science. Explore our Pro Resolving Mediators +EPA /DHA.
References
-
Basil, M. C., & Levy, B. D. (2016). Specialized pro-resolving mediators: Endogenous regulators of infection and inflammation. Nature Reviews Immunology, 16(1), 51-67. https://pubmed.ncbi.nlm.nih.gov/26688348/
-
Chiang, N., & Serhan, C. N. (2020). Specialized pro-resolving mediator network: An update on production and actions. FASEB Journal, 34(12), 15550-15570. https://pubmed.ncbi.nlm.nih.gov/32885825/
-
Dalli, J., & Serhan, C. N. (2012). Specific lipid mediator signatures of human phagocytes: Resolvin D1 and resolvin D2 biosynthesis during acute inflammation and resolution. Journal of Immunology, 188(9), 4527-4534. https://www.jci.org/articles/view/97943
-
Markworth, J. F., Vella, L., Figueiredo, V. C., & Cameron-Smith, D. (2014). Resolvin D1 supports skeletal muscle regeneration via actions on myoblasts and macrophages. Journal of Applied Physiology, 116(12), 1625-1632.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5892385/
-
Serhan, C. N., & Levy, B. D. (2018). Resolvins in inflammation: Emergence of the pro-resolving superfamily of mediators. Journal of Clinical Investigation, 128(7), 2657-2669. hhttps://pubmed.ncbi.nlm.nih.gov/29757195/
-
Serhan, C. N., Chiang, N., & Van Dyke, T. E. (2015). Resolving inflammation: Dual anti-inflammatory and pro-resolution lipid mediators. Nature Reviews Immunology, 15(1), 45-56. https://pubmed.ncbi.nlm.nih.gov/18437155/
Everything You Need to Know About PRMs
PRM FAQs: Everything You Need to Know About Pro-Resolving Mediators
The more we learn about the role that chronic inflammation plays in our longevity and performance, the more we look to Pro-Resolving Mediators (PRMs) as an innovative tool in safely offsetting the negative effects of inflammation.
But what exactly are PRMs, and how can they benefit you? In this article we’ll answer the common questions about PRMs, breaking down their science, benefits, and practical applications, with insights from scientific literature.
What Are PRMs?
PRMs, short for Pro-Resolving Mediators, are specialized lipid compounds derived from omega-3 fatty acids such as EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid). Unlike traditional anti-inflammatory approaches that suppress inflammation, PRMs actively work to resolve it by supporting the body’s natural inflammation resolution process (Serhan & Levy, 2018).
When your body experiences inflammation—whether from exercise, injury, or illness it’s not just the onset of inflammation that matters, the resolution phase is equally critical. PRMs help by:
Clearing cellular debris and promoting tissue repair (Serhan et al., 2015).
Inhibiting excessive inflammation that can lead to chronic conditions (Chiang & Serhan, 2020).
Supporting immune homeostasis and recovery from injury (Basil & Levy, 2016).
In simple terms, PRMs ensure your body completes the natural inflammation cycle, preventing prolonged or chronic inflammation.
Why Are PRMs Important for Athletes and High Performers?
Whether you’re an athlete or someone pushing physical limits, inflammation is a natural part of recovery. However, prolonged or unresolved inflammation can hinder performance and increase injury risk. Here’s why PRMs are a game-changer:
Faster Recovery
PRMs accelerate the resolution of post-exercise inflammation, reducing muscle soreness and promoting quicker recovery (Dalli & Serhan, 2012).
Joint and Tissue Health
By resolving low-grade chronic inflammation, PRMs help protect against long-term joint and tissue damage, which is common in overuse injuries (Serhan et al., 2015).
Non-Disruptive to Adaptation
Unlike NSAIDs, which may blunt the muscle adaptation process, PRMs naturally resolve inflammation without interfering with strength and endurance gains (Markworth et al., 2014).
For high performers, PRMs offer a targeted solution to recover effectively and stay competitive without relying on pharmaceuticals.
How Are PRMs Different From Omega-3s?
While omega-3s like EPA and DHA are precursors to PRMs, not all omega-3 supplements contain PRMs themselves. PRMs are the active metabolites your body produces from omega-3s, which directly mediate the resolution of inflammation (Serhan et al., 2015). PRM supplements deliver these bioactive compounds directly, offering a more targeted approach.
Are PRMs Safe?
Yes, PRMs are safe and well-tolerated. Unlike NSAIDs, PRMs don’t carry the risk of gastrointestinal issues or interfere with muscle adaptation. However, individuals on blood-thinning medications or with specific health conditions should consult a healthcare provider before use (Basil & Levy, 2016).
Conclusion
Pro-resolving mediators represent a paradigm shift in inflammation management, offering a natural, efficient, and evidence-based way to optimize recovery and support long-term health.
PRMs are designed to help you recover smarter, perform better, and stay ahead of inflammation.
At Spoken, we’re committed to delivering the highest-quality supplements backed by science. Explore our Pro Resolving Mediators +EPA /DHA.
References
Basil, M. C., & Levy, B. D. (2016). Specialized pro-resolving mediators: Endogenous regulators of infection and inflammation. Nature Reviews Immunology, 16(1), 51-67. https://pubmed.ncbi.nlm.nih.gov/26688348/
Chiang, N., & Serhan, C. N. (2020). Specialized pro-resolving mediator network: An update on production and actions. FASEB Journal, 34(12), 15550-15570. https://pubmed.ncbi.nlm.nih.gov/32885825/
Dalli, J., & Serhan, C. N. (2012). Specific lipid mediator signatures of human phagocytes: Resolvin D1 and resolvin D2 biosynthesis during acute inflammation and resolution. Journal of Immunology, 188(9), 4527-4534. https://www.jci.org/articles/view/97943
Markworth, J. F., Vella, L., Figueiredo, V. C., & Cameron-Smith, D. (2014). Resolvin D1 supports skeletal muscle regeneration via actions on myoblasts and macrophages. Journal of Applied Physiology, 116(12), 1625-1632.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5892385/
Serhan, C. N., & Levy, B. D. (2018). Resolvins in inflammation: Emergence of the pro-resolving superfamily of mediators. Journal of Clinical Investigation, 128(7), 2657-2669. hhttps://pubmed.ncbi.nlm.nih.gov/29757195/
Serhan, C. N., Chiang, N., & Van Dyke, T. E. (2015). Resolving inflammation: Dual anti-inflammatory and pro-resolution lipid mediators. Nature Reviews Immunology, 15(1), 45-56. https://pubmed.ncbi.nlm.nih.gov/18437155/